Nitrosigine may outperform other sports nutrition ingredients for NO production: Study

Arginine is a precursor to the potent vasodilator nitric oxide (NO), a compound which primarily dilates blood vessels and improves blood flow.  This therefore has implications for cardiovascular health and sports performance.

Data presented at the International Society of Sports Nutrition 13th Annual Conference indicated that Nitrosigine led to significantly increased NO levels in an in vitro model more than arginine AKG, L-arginine, agmatine sulfate, L-citrulline, and L-citrulline malate.

The study also showed that supplementation with the inositol-stabilized arginine silicate, in comparison to the other ingredients, was the only one to increase NO production significantly compared to control.

“Increasing NO can lead to substantial benefits for training athletes and fitness enthusiasts as it can result in enhanced delivery of oxygen and nutrients to working muscles, positively affecting workouts and recovery,” ​said the company in a press release.  

Commenting on the study’s findings, James Komorowski, VP of scientific & regulatory affairs of Nutrition 21 said: “The results of this study provide additional information to help us better understand the enhanced effects reported on Nitrosigine.”​

Joe Weiss, the company’s president, added: “This study is another example of how Nutrition 21 demonstrates the efficacy of its products and has created a leading branded ingredient in the sports nutrition category.”​

Versus individual components​

Data was also presented at the ISSN meeting that showed that the bonded arginine silicate complex was more effective at increasing serum arginine and silicon levels compared to equivalent doses of arginine, silicon and inositol as individual components.

The study also reportedly showed that Nitrosigine significantly increased serum and joint tissue arginine and silicon levels compared to the control groups and the individual component group.

“The results of this study demonstrate that the activity of the inositol-stabilized arginine silicate complex is different than activity seen with each of the individual components.  As a result, the benefits seen in clinical studies are specific to the bonded complex,” ​said Komorowski.

Source: ISSN 13th Annual Conference​​
Presented June 11, 2016
“Comparison of Cellular Nitric Oxide Production from Various Sports Nutrition Ingredients” 

“Absorption of Bonded Arginine Silicate Compared to Individual Arginine and Silicon Components”