Probiotical S.p.A. developed an innovative range of probiotics (BifiZen®) for mental wellbeing based on a high-potential probiotic combination of four different strains (L. fermentum LF16, L. rhamnosus LR06, L. plantarum LP01 and B. longum 04), that were selected based on in silico, in vitro and preclinical studies.
Three clinical studies demonstrated the benefit of BifiZen®, that significantly and consistently improved several aspects of mood, with a reduction in depressive mood state, anger and fatigue, and improvement of acceptance and sleep quality in a young and healthy cohort.