The ingredients are processed with Tradichem’s patented Hipering granulation and compaction technology.
“We are extremely proud of our technology,” says Dr José Ángel Marañón, Executive Vice President of Tradichem and founder of its manufacturing subsidiary TIS.
“We look forward to continuing to expand our Hipering ingredients portfolio and exploring new business opportunities together with a global partner like Cellmark.”
The high-tech Hipering edge
TIS launched the Hipering technology in 2016 at its pharmaceutical and nutraceutical manufacturing facility just outside of Madrid. The site is designed to process more than 300 tons of free-flowing raw materials annually, maximising efficiency and ensuring the integrity of the ingredients.
“Hipering technology is based on a sequence of processes that modify the physical properties of the starting material while keeping its purity and chemical specifications intact,” TIS explained in a statement.
“This translates into a very significant increase in the operational efficiency for API manufacturers and drug manufacturers of finished dosage forms, together with a dramatic impact on the reduction of industrial costs.”
The company estimates a 50% to 70% increase in operational efficiency for manufacturers and highlights that the technology is an environmentally friendly physical process that does not use excipients, solvents or reagents. It currently holds six European patents and one US patent, including those for the processing of granular quercetin and granular CoQ10.
Granular quercetin and granular CoQ10
Regular quercetin and regular CoQ10 are sticky hygroscopic materials, TIS explains, but the granular quercetin and granular CoQ10 obtained through this technology are free-flowing powders with “unique and outstanding fluidity properties” especially intended for the manufacturing of solid dosage forms.
“Sticky hygroscopic powders are hard to handle, and the yield of manufacturing of capsules/tablets is poor because of the properties of the raw material,” Marañón told NutraIngredients.
“For instance, with a regular quercetin you cannot produce more than 20,000 capsules per hour, and you will have to stop the process for cleaning the equipment and retiring the sticky powder.”
By eliminating these stoppages, he says that the Hipering technology can produce more than 50,000 quercetin capsules per hour.
Both quercetin and CoQ10 are potent antioxidants found naturally within the body and marketed in supplement form to boost immunity, improve heart and brain health, and fight chronic disease. Marañon says that TIS is currently the world’s only producer of granular CoQ10, registering a purity of 99.5%.
The granular ingredients join a portfolio of more than 500 products distributed by Cellmark in the industrial, health and personal care markets through a global network of offices in 30 countries.
“The spirit of the agreement and the partnership with Tradichem are fully aligned with a common scope of bringing knowledge and real value to our customers and providing high quality products, technical expertise, exceptional customer service and competitive pricing,” adds Ray Bartone, Director of CellMark USA.
