science short

Chilli pepper capsaicin may inhibit gut tumours & extend mice lifespan by 30%: Research

By Annie Harrison-Dunn

- Last updated on GMT

“Our data also suggested that TRPV1 triggering by dietary administration of capsaicin suppressed intestinal tumourigenesis,” say researchers. Photo credit: Julie Gibbons.
“Our data also suggested that TRPV1 triggering by dietary administration of capsaicin suppressed intestinal tumourigenesis,” say researchers. Photo credit: Julie Gibbons.
Dietary capsaicin – the active ingredient found in chilli peppers – may trigger a reaction that reduces the risk of colorectal tumours, according to Californian research on mice.

Treatment of the tumour-prone mice with capsaicin reduced tumour burden and extended the lifespans of the mice by over 30%.  

The research, published this month in The Journal of Clinical Investigation, ​said the active ingredient produced chronic activation of a receptor, TRPV1, on cells lining the intestines of mice genetically modified to be TRPV1-deficient, which in turn triggered the reaction.

“Our data also suggested that TRPV1 triggering by dietary administration of capsaicin suppressed intestinal tumourigenesis,”​ the researchers said.

As a result they recommended the administration of TRPV1 agonists like capsaicin in combination with celecoxib, a COX-2 non-steroidal anti-inflammatory drug that treats some forms of arthritis and pain.

Intestinal expression

The receptor or ion channel TRPV1 was originally discovered in sensory neurons, where it acts as a guard against heat, acidity and chemicals in the environment. This latest research found that the receptor was also expressed by intestinal epithelial cells.

The scientists discovered that TRPV1 works as a tumor suppressor in the intestines through a “feedback loop”​ with the epidermal growth factor receptor (EGFR), reducing the risk of unwanted growth.

Dr Petrus de Jong, one of the study’s authors, said: "A basic level of EGFR activity is required to maintain the normal cell turnover in the gut. However, if EGFR signaling is left unrestrained, the risk of sporadic tumor development increases."

Professor Eyal Raz, another of the study’s authors, said: "Our data suggest that individuals at high risk of developing recurrent intestinal tumors may benefit from chronic TRPV1 activation.”

We have provided proof-of-principle.”

Source: The Journal of Clinical Investigation

Published online ahead of print, doi:10.1172/JCI72340

“Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis”

Authors: P.R. de Jong, N. Takahashi, A.R. Harris, J. Lee, S.  Bertin,J. Jeffries, M. Jung, J. Duong, A.I. Triano, J. Lee, Y. Niv,D.S. Herdman, K. Taniguchi, C.W. Kim, H. Dong, L. Eckmann,S.M. Stanford, N. Bottini, M. Corr and E. Raz

Related news

Show more

Related products

show more

Fueling Athletes with Nature for Peak Performance

Fueling Athletes with Nature for Peak Performance

Content provided by SEPPIC INC | 07-Oct-2024 | White Paper

For many years, pine bark extracts have been harnessed for their potent anti-oxidant and anti-inflammatory properties, delivering a wide array of health...

ACTRISAVE™ NATURAL SUPPORT FOR SKIN AND MALE HAIR

ACTRISAVE™ NATURAL SUPPORT FOR SKIN AND MALE HAIR

Content provided by BIONAP BIOACTIVE NATURAL PRODUCTS | 30-Sep-2024 | Product Brochure

ACTRISAVE™ is a powdered extract obtained from the patented association between black rice (Oryza sativa L.) and the flowers of prickly pear (Opuntia ficus-indica...

Tackling Metabolic Health with HIMABERB® Berberine

Tackling Metabolic Health with HIMABERB® Berberine

Content provided by Pharma Base S.A. | 18-Sep-2024 | White Paper

Metabolic health is a prevalent and rapidly growing global challenge. In recent years, there has been mounting clinical evidence to support the use of...

Fast acting Specialty Lutein Esters

Fast acting Specialty Lutein Esters

Content provided by Ennature Biopharma, a Division of India Glycols Limited | 16-Sep-2024 | Case Study

Xanthogreen® is a clinically validated, clean label ingredient from marigold flowers that helps boost your eye health with visible effects in as little...

Related suppliers

Follow us

Products

View more

Webinars