Polymethoxylated flavones (PMFs) are citrus ingredients used for heart health applications. Where Vesisorb can help is in boosting the rate at which they are absorbed into the human body.
Citrus CMFs are notoriously poorly absorbed in the body, according to Dr Andreas Supersaxo, R&D director at Swiss firm Vesifact, which developed the delivery system.
Bioavailability study
To put it to the test a bioavailability study was conducted (single oral dose, double-blind, crossover design) to compare standard PMF powder with SourceOne’s PMF-Source and the Vesisorb delivery system.
What the test results indicate, according to SourceOne, which holds the exclusive global licensing rights for the Vesisorb technology, is that PMF absorption of the Vesisorb formulation was significantly improved and faster compared to standard PMF. Peak plasma levels (Cmax) of Nobiletin, Tangeretin and their metabolites were increased by up to 800 per cent.
Supersaxo said the results demonstrate the “clear potential for greater efficacy and improved health and wellness for formulations containing Citrus PMF, HO-PMFs, Citrus Limonoids, and Eriocitrin/Eriodictyol.”
Recent studies
Research on the effect of Vesisorb on PMF-Source follows on from studies regarding its impact on the absorption of Omega-3 and CoQ10.
SourceOne highlighted two pharmacokinetic studies on Omega-3 and CoQ10 that both compared formulations using the Vesifact delivery system with ones without. They recorded increases in bioavailability of 485 percent in the case of CoQ10 and 487 percent for Omega-3.
“These results, including the newest study, highlight the many advantages that this delivery system represents,” said Vesifact CEO Marc Weder. “We have been able to broaden the applications for certain bioactive ingredients like PMFs, CoQ10, and omega 3 into functional ingredients, beverages, and cosmetic products.”